Publications


Origin of life

 

Book



Eric Smith and Harold Morowitz, The Origin and Nature of Life on Earth: The Emergence of the Fourth Geosphere (Cambridge, London, 2016)


Articles


Rogier Braakman and Eric Smith, Metabolic evolution of a deep-branching hyperthermophilic chemoautotrophic bacterium, PLoS ONE. 9:e87950 (2014) PDF


Rogier Braakman and Eric Smith, The compositional and evolutionary logic of metabolism, Phys. Biol. 10:011001 (2013) PDF


Rogier Braakman and Eric Smith, The emergence and early evolution of biological carbon fixation, PLoS Comp. Biol. 8:e1002455 (2012) PDF


Harold J. Morowitz, Vijayasarathy Srinivasan, and Eric Smith, Ligand field theory and the origin of life as an emergent feature of the periodic table of the elements, Biol. Bull. 219:1--6 (2010) PDF


Eric Smith and Harold J. Morowitz, The autotrophic origins paradigm and small-molecule organocatalysis. Orig. Life Evol. Biosphere 40:397--402 (2010) PDF


Eric Smith and Harold J. Morowitz, Confederacy based on synthetic-pathway and bio-energetic modularity.  Orig. Life Evol. Biosphere 40:467--475 (2010) PDF


Harold J. Morowitz and Eric Smith, Energy flow and the organization of life. Complexity 13:51--59 (2007) PDF


Shelley D. Copley, Eric Smith, and Harold J. Morowitz, The origin of the RNA world: Co-evolution of genes and metabolism. Bioorganic Chemistry 35:430--443 (2007) PDF


Shelley D. Copley, Eric Smith, and Harold J. Morowitz, A mechanism for the association of amino acids with their codons and the origin of the genetic code. Proc. Nat. Acad. Sci. USA 102:4442--4447(2005) PDF


Eric Smith and Harold J. Morowitz, Universality in intermediary metabolism. Proc. Nat. Acad. Sci. USA 101:13168--13173 (2004) PDF



Book chapters


Eric Smith, Emergent order in processes: the interplay of complexity,  robustness, correlation, and hierarchy in the biosphere.  for The self-organizing universe: cosmology, biology, and the rise of complexity, Charles Lineweaver, Paul Davies, and

Michael Ruse eds. (Cambridge, MA 2012. Cambridge U.~Press, in press)


Shelley D. Copley, Eric Smith, and Harold J. Morowitz, The emergence of sparse metabolic networks, in Abiogenesis and the origins of life, Michael, Russell, ed. (Cosmo. Sci. Publishers, Cambridge, MA, 2010) p.175--191


Eric Smith, Harold J. Morowitz, and Shelley D. Copley, Core metabolism as a self-organizing system. in Steen Rasmussen, Norman Packard, and Marc Bedau, editors, Protocells: Bridging nonliving and living matter (Cambridge, Mass., MIT Press, 2009), p. 433--460


Eric Smith and Harold J. Morowitz, Framing the question of fine-tuning for intermediary metabolism. in John D. Barrow, Simon Conway Morris, Stephen J. Freeland, and Charles L. Harper, editors, Fitness of the Cosmos for Life: Biochemistry and Fine-Tuning (Cambridge U. Press, San Francisco, CA., 2007). p. 384--420



Essays and semipopular


James Trefil, Harold J. Morowitz, and Eric Smith, The Origin of LIfe, American Scientist 97:206--213 PDF


Harold J. Morowitz, Eric Smith, and Vijayasarathy Srinivasan, Selfish metabolism. Complexity 14:7--9 (2009) PDF


Eric Smith, Before Darwin, The Scientist 22:32--38 (2008)


Vijayasarathy Srinivasan, Harold J. Morowitz, and Eric Smith, Essential amino acids, from LUCA to Lucy. Complexity 13:8--9 (2008) PDF


Lokesh Joshi, Eric Smith , and Harold J. Morowitz, Glycobiology: the sweet language of life, complexity, and morphogenesis. Complexity 12:9--10 (2007)


Eric Smith, Harold J. Morowitz, and Vijayasarathy Srinivasan, Experimental search for the minimal organisms and the last universal common ancestor. Complexity 12:11--12(2007) PDF


Harold J. Morowitz, Vijayasarathy Srinivasan, and Eric Smith, The swiss army knife of biological catalysis. Complexity 11:9--10 (2006) PDF


Harold J. Morowitz, Vijayasarathy Srinivasan, Shelley D. Copley, and Eric Smith, The simplest enzyme revisited. Complexity 10:12--13 (2005) PDF